Topic

Evidence Critique

Where the popular health-science narrative breaks. Keto trials and their retractions, the LMHR hypothesis, supplement marketing, and the difference between mechanism and outcome data.

6 articles

A dark hero card reading I was ready to pay to watch my plaque shrink, then I learned the number moves on its own, beside an abstract image of a coronary CT scan being measured.
Diagnostic ToolkitEvidence Critique

I Was Ready to Pay to Watch My Plaque Shrink. Then I Learned the Number Moves on Its Own.

AI plaque analysis from Cleerly and HeartFlow measures arteries to the cubic millimeter. Rescan an hour later and the number moves. Read before you pay for one.

Aug 13, 2026 · 16 min read
Calibrated Signal featured card: Zombie Cells Have an Inflammatory Fuel Line. A senescent cell in luminous cross-section, with glowing mitochondria feeding a thin line of light through a valve toward an opening coil of DNA.
Aging BiologyEvidence Critique

Aging's Zombie Cells Have an Inflammatory Fuel Line. Mayo Just Found the Valve.

A Mayo-led Nature study shows how mitochondrial metabolism opens inflammatory genes in senescent cells, tying several hallmarks of aging into one circuit behind inflammation.

Aug 2, 2026 · 16 min read
Calibrated Signal hero card reading 'Real Mechanism. Wrong Certainty.' over a stylized coronary artery, with the line: 5-Amino-1MQ, injected mice, and the heart arrow nobody measured.
InterventionsEvidence Critique

The Longevity Compound Promoted on Half a Mechanism

Its entire case for your heart is one biochemical arrow. I followed the other one, the one that runs the wrong way, and as a guy with a stent I walked away.

Jul 2, 2026 · 11 min read
A left-to-right flow diagram on a dark background reading: Metformin, acts in the gut, less citrulline, less nitric oxide, less blood flow to muscle. The heading reads, the concern did not disappear, it moved upstream.
Aging BiologyInterventions

The Gut May Be the Point: Metformin, Citrulline, and the Exercise Question

A new Nature Metabolism paper places metformin's main effect in the gut, not muscle. That eases one exercise-blunting fear and raises a sharper one: citrulline and nitric oxide.

Jun 3, 2026 · 13 min read
Calibrated Signal featured card: Metabolically Healthy Isn’t a Diagnosis, a coronary artery cross-section with soft yellow plaque on dark navy.
Evidence CritiqueCardiovascular Risk

I Was “Metabolically Healthy.” I Got a Stent at 44 Anyway.

Low hsCRP, a flat CGM, no insulin resistance: every marker the low-carb world calls “safe.” Then a CT angiogram found an 80% blockage in my right coronary artery.

Apr 24, 2026 · 14 min read
Calibrated Signal featured card: The Keto Study Used to Dismiss LDL, Then It Was Retracted — an artery cross-section with glowing plaque on dark navy.
Evidence CritiqueCardiovascular Risk

The Study the Keto Community Uses to Say LDL Doesn’t Matter. Then the Follow-Up Got Retracted.

A keto study is cited to argue high LDL is harmless when metabolic markers are clean. The follow-up that measured soft plaque was retracted in 2026. Here's what the evidence shows.

Mar 27, 2026 · 16 min read