Topic
Evidence Critique
Where the popular health-science narrative breaks. Keto trials and their retractions, the LMHR hypothesis, supplement marketing, and the difference between mechanism and outcome data.
9 articles
What "This Supplement Has a Solid Mechanism" Actually Means
Resveratrol only switched on its aging enzyme when a glowing dye was attached. What a solid supplement mechanism means, and why dose and route still decide.
Two Big Glasses of Wine a Night Is Officially “Heavy Drinking”
One or two glasses of red wine with dinner. Not a night out. The next morning my overnight heart rate was up as much as 20 percent, and my heart rate variability was cut by as much as half.
I Went Into Research to Study Aging. Then I Needed a Stent at 44.
What aging biology can tell us about the supplements, tests and habits we pay for: the 12 hallmarks of aging, plus a candidate 13th, in plain English.
I Was Ready to Pay to Watch My Plaque Shrink. Then I Learned the Number Moves on Its Own.
AI plaque analysis from Cleerly and HeartFlow measures arteries to the cubic millimeter. Rescan an hour later and the number moves. Read before you pay for one.
Aging's Zombie Cells Have an Inflammatory Fuel Line. Mayo Just Found the Valve.
Why zombie cells fuel inflammaging: a Mayo-led Nature study traces the mitochondrial fuel line that keeps inflammation genes open, and the valve that shuts it.
The Longevity Compound Promoted on Half a Mechanism
5-Amino-1MQ, the NNMT inhibitor sold for fat loss and longevity: injected-mouse results, efficacy studies from the lab behind the patent, zero human trials.
The Gut May Be the Point: Metformin, Citrulline, and the Exercise Question
Metformin acts mainly in the gut, not muscle, per Nature Metabolism. That eases one exercise fear and raises a sharper one: less citrulline, less nitric oxide.
I Was “Metabolically Healthy.” I Got a Stent at 44 Anyway.
Low hsCRP, flat CGM, no insulin resistance, LDL 150s on keto: every marker the low-carb world calls safe. Then a CT angiogram found an 80% blockage at 44.
The Study the Keto Community Uses to Say LDL Doesn’t Matter. Then the Follow-Up Got Retracted.
The Keto-CTA follow-up was retracted in 2026 at the authors' and editors' request over methodology. What soft plaque did in one year, and why LDL still matters.