Topic

Diagnostic Toolkit

What the tests can and cannot see. Why standard cardiac workups miss subclinical disease, what CCTA and calcium scoring actually measure, and how to advocate for the right scan.

11 articles

Calibrated Signal featured card: What Keeps Plaque in Your Heart Arteries From Rupturing? A cutaway of a coronary artery plaque whose thin fibrous cap is tearing open above an amber lipid core, with a clot forming at the tear.
Cardiovascular RiskAging Biology

What Keeps Plaque in Your Heart Arteries From Rupturing?

Is soft plaque dangerous? Whether a plaque ruptures depends on its fibrous cap, which no CT report measures. What thins it, and the trials where caps thickened.

Sep 24, 2026 · 21 min read
Calibrated Signal featured card: Your Angiogram Was Clean. Nobody Tested Whether Your Artery Clamps. A cutaway of a coronary artery with its muscular wall contracting, for the article on how coronary artery spasm is diagnosed in the cath lab.
Diagnostic ToolkitPatient Advocacy

Your Angiogram Was Clean. Nobody Tested Whether Your Artery Clamps.

Coronary artery spasm is diagnosed with an acetylcholine test in the cath lab, not an angiogram. What it measures, why it is rarely run, how drugs blunt it.

Sep 9, 2026 · 24 min read
Nick Hanson lying in a hospital bed in a patient gown with a cold cloth on his forehead and IV lines in both arms, the day of his coronary artery spasm diagnosis workup.
Patient AdvocacyDiagnostic Toolkit

I Finally Have the Diagnosis That Explains Years of Chest Pressure. It Wasn't Anxiety. It Was Never "All in My Head."

A stent didn't stop the episodes. Every scan said fine. The answer came from the one test I almost turned down.

Aug 31, 2026 · 14 min read
A dark hero card reading I was ready to pay to watch my plaque shrink, then I learned the number moves on its own, beside an abstract image of a coronary CT scan being measured.
Diagnostic ToolkitEvidence Critique

I Was Ready to Pay to Watch My Plaque Shrink. Then I Learned the Number Moves on Its Own.

AI plaque analysis from Cleerly and HeartFlow measures arteries to the cubic millimeter. Rescan an hour later and the number moves. Read before you pay for one.

Aug 13, 2026 · 16 min read
Calibrated Signal hero card for I Crushed My ApoB to 38, Nobody Measured My Small Vessels: a wide open coronary artery in cross-section branching downstream into a dense network of tiny inflamed red micro-vessels, the coronary microvasculature.
Cardiovascular RiskAging Biology

I Crushed My ApoB to 38. Nobody Measured My Small Vessels.

Coronary microvascular dysfunction hides behind a clean angiogram. How it is diagnosed, why inflammation drives it, and why an ApoB of 38 was not enough.

Jul 27, 2026 · 14 min read
Calibrated Signal hero card for The Heart-Attack Risk Hiding in Your Immune Cells: one rogue blood cell from a clonal hematopoiesis (CHIP) mutation among normal immune cells, with a DNA strand carrying one break.
Aging BiologyDiagnostic Toolkit

The Heart-Attack Risk Hiding in Your Immune Cells

Clonal hematopoiesis (CHIP): a blood mutation that roughly doubles coronary risk. No cardiology society screens for it. Why, and why I stopped chasing the test.

Jul 14, 2026 · 27 min read
Calibrated Signal hero card for The Question No One Asked: what a stent procedure can and cannot tell you about a silent heart attack.
Diagnostic ToolkitPatient Advocacy

The Question No One Asked

A stent fixed my blockage. No cath-lab test could say whether a silent heart attack had already left a scar. Cardiac MRI can, and a stent doesn't rule it out.

Jun 29, 2026 · 12 min read
Calibrated Signal article hero card for The Plaque a Calcium Score Can't See, contrasting a calcium-only heart scan with a coronary CT angiogram that reveals soft plaque.
Diagnostic ToolkitCardiovascular Risk

The Plaque a Calcium Score Can't See

A calcium score only sees calcified plaque. Mine would have read zero with a severe soft-plaque blockage in place. What a 0 rules out, and what it doesn't.

Jun 11, 2026 · 10 min read
Calibrated Signal featured card: The Battle for the Coronary Artery Scan That Saved My Life, a translucent heart inside a coronary CT angiography scanner ring on dark navy.
Diagnostic ToolkitPatient Advocacy

The Battle for the Coronary Artery Scan That Saved My Life

ECG, echo, Holter, stress test: all normal. A coronary CT angiogram (CCTA) found an 80% blockage anyway. What it shows, and the exact words to ask for it.

Mar 30, 2026 · 14 min read
A grid of cardiac and metabolic test results, exercise stress test, resting ECG, Holter monitor, echocardiogram, a metabolic panel, and lipoprotein(a), each marked NORMAL with a green check.
Diagnostic ToolkitPatient Advocacy

I Aced Every Cardiac Test. I Still Had an 80% Blockage.

My ECG, echo and Holter all missed an 80% blockage. Only two tests see plaque in the artery: a calcium score and a CT angiogram (CCTA). Which one to ask for.

Mar 29, 2026 · 14 min read
Calibrated Signal featured card: 80 percent heart blockage at 44, every test said fine. A translucent heart with copper coronary arteries on dark navy.
Patient AdvocacyDiagnostic Toolkit

I Had an 80% Coronary Blockage at 44. Every Test Said I Was Fine.

Every test was normal at 44: ECG, echo, Holter. Then a CT angiogram found an 80 percent heart blockage. How serious that is, and the fight to get the scan.

Mar 24, 2026 · 9 min read