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Evidence-first investigations of health and longevity claims: cardiovascular risk, the biology of aging, and the gap between standard cardiac testing and what’s actually accumulating in your arteries.
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Two Big Glasses of Wine a Night Is Officially “Heavy Drinking”
One or two glasses of red wine with dinner. Not a night out. The next morning my overnight heart rate was up as much as 20 percent, and my heart rate variability was cut by as much as half.
I Went Into Research to Study Aging. Then I Needed a Stent at 44.
What aging biology can tell us about the supplements, tests and habits we pay for: the 12 hallmarks of aging, plus a candidate 13th, in plain English.
Is Your Mouthwash Increasing Your Blood Pressure?
Some mouthwashes shut down the tongue bacteria your body uses to make nitric oxide. What chlorhexidine does to blood pressure, and which rinse didn't.
What Keeps Plaque in Your Heart Arteries From Rupturing?
Is soft plaque dangerous? Whether a plaque ruptures depends on its fibrous cap, which no CT report measures. What thins it, and the trials where caps thickened.
Your Angiogram Was Clean. Nobody Tested Whether Your Artery Clamps.
Coronary artery spasm is diagnosed with an acetylcholine test in the cath lab, not an angiogram. What it measures, why it is rarely run, how drugs blunt it.
I Finally Have the Diagnosis That Explains Years of Chest Pressure. It Wasn't Anxiety. It Was Never "All in My Head."
A stent didn't stop the episodes. Every scan said fine. The answer came from the one test I almost turned down.
I Was Ready to Pay to Watch My Plaque Shrink. Then I Learned the Number Moves on Its Own.
AI plaque analysis from Cleerly and HeartFlow measures arteries to the cubic millimeter. Rescan an hour later and the number moves. Read before you pay for one.
Aging's Zombie Cells Have an Inflammatory Fuel Line. Mayo Just Found the Valve.
Why zombie cells fuel inflammaging: a Mayo-led Nature study traces the mitochondrial fuel line that keeps inflammation genes open, and the valve that shuts it.
I Crushed My ApoB to 38. Nobody Measured My Small Vessels.
Coronary microvascular dysfunction hides behind a clean angiogram. How it is diagnosed, why inflammation drives it, and why an ApoB of 38 was not enough.
The Heart-Attack Risk Hiding in Your Immune Cells
Clonal hematopoiesis (CHIP): a blood mutation that roughly doubles coronary risk. No cardiology society screens for it. Why, and why I stopped chasing the test.
The Longevity Compound Promoted on Half a Mechanism
5-Amino-1MQ, the NNMT inhibitor sold for fat loss and longevity: injected-mouse results, efficacy studies from the lab behind the patent, zero human trials.
The Question No One Asked
A stent fixed my blockage. No cath-lab test could say whether a silent heart attack had already left a scar. Cardiac MRI can, and a stent doesn't rule it out.
The Heart Attacks You Never Feel
What happens when coronary plaque ruptures and heals instead of killing you: a silent wound that narrows the artery. It likely built my 80% blockage at 44.
The Plaque a Calcium Score Can't See
A calcium score only sees calcified plaque. Mine would have read zero with a severe soft-plaque blockage in place. What a 0 rules out, and what it doesn't.
The Gut May Be the Point: Metformin, Citrulline, and the Exercise Question
Metformin acts mainly in the gut, not muscle, per Nature Metabolism. That eases one exercise fear and raises a sharper one: less citrulline, less nitric oxide.
I Trained Hard for 25 Years. I Was Measuring the Wrong Fitness.
VO2 max carries one of the strongest survival signals in medicine, with no ceiling found. I lifted five hours a week for 25 years and never measured mine once.
Blood Pressure Isn’t a Moment. It’s a Dose Your Arteries Absorb for Decades.
132/85 is now Stage 1 hypertension, and a single reading is one sample of a dose your arteries absorb every beat, for decades. Mine sat there for twenty years.
What Twenty Years of “Borderline” LDL Actually Costs You
An LDL of 145 at 35 isn’t a snapshot. It’s 2,175 mg-years of exposure your arteries have already logged, and “borderline” is the word that hides the bill.
I Was “Metabolically Healthy.” I Got a Stent at 44 Anyway.
Low hsCRP, flat CGM, no insulin resistance, LDL 150s on keto: every marker the low-carb world calls safe. Then a CT angiogram found an 80% blockage at 44.
I Was Doing Almost Everything Right. It Wasn’t Enough.
The perfect biohacker résumé: 30 years of training, a supplement stack, wearables, clean labs. None of it measured the artery wall where an 80% blockage grew.
The Battle for the Coronary Artery Scan That Saved My Life
ECG, echo, Holter, stress test: all normal. A coronary CT angiogram (CCTA) found an 80% blockage anyway. What it shows, and the exact words to ask for it.
I Aced Every Cardiac Test. I Still Had an 80% Blockage.
My ECG, echo and Holter all missed an 80% blockage. Only two tests see plaque in the artery: a calcium score and a CT angiogram (CCTA). Which one to ask for.
The Study the Keto Community Uses to Say LDL Doesn’t Matter. Then the Follow-Up Got Retracted.
The Keto-CTA follow-up was retracted in 2026 at the authors' and editors' request over methodology. What soft plaque did in one year, and why LDL still matters.
I Had an 80% Coronary Blockage at 44. Every Test Said I Was Fine.
Every test was normal at 44: ECG, echo, Holter. Then a CT angiogram found an 80 percent heart blockage. How serious that is, and the fight to get the scan.
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