Topic
Aging Biology
The hallmarks of aging — mitochondrial dysfunction, inflammaging, intercellular signaling, the systems-level vocabulary for why human bodies break down with time.
5 articles
I Crushed My ApoB to 38. Nobody Measured My Small Vessels.
Cholesterol is half the job. Inflammation in the microvasculature is the other half, and it is the layer a standard cardiac workup never actually measures.
The Heart-Attack Risk Hiding in Your Immune Cells
A blood mutation called CHIP turns your own immune cells against your arteries, and it is the cleanest case study I know for how the biology of aging drives chronic disease.
The Gut May Be the Point: Metformin, Citrulline, and the Exercise Question
A new Nature Metabolism paper places metformin's main effect in the gut, not muscle. That eases one exercise-blunting fear and raises a sharper one: citrulline and nitric oxide.
I Trained Hard for 25 Years. I Was Measuring the Wrong Fitness.
I trained hard for 25 years and never once measured my cardiorespiratory fitness. A hard program isn't a complete one, and the system you train best hides the ones you never test.
What Twenty Years of “Borderline” Blood Pressure Actually Costs You
A single 132/85 at 35 isn’t a snapshot. It’s a 20-year dose your arteries are already logging, and “borderline” is the word that hides the bill.