Topic
Aging Biology
The hallmarks of aging — mitochondrial dysfunction, inflammaging, intercellular signaling, the systems-level vocabulary for why human bodies break down with time.
7 articles
Your Angiogram Was Clean. Nobody Tested Whether Your Artery Clamps.
Coronary artery spasm is diagnosed with an acetylcholine test in the cath lab, not an angiogram. What it measures, why it is rarely run, how drugs blunt it.
Aging's Zombie Cells Have an Inflammatory Fuel Line. Mayo Just Found the Valve.
A Mayo-led Nature study shows how mitochondrial metabolism opens inflammatory genes in senescent cells, tying several hallmarks of aging into one circuit behind inflammation.
I Crushed My ApoB to 38. Nobody Measured My Small Vessels.
Cholesterol is half the job. Inflammation in the microvasculature is the other half, and it is the layer a standard cardiac workup never actually measures.
The Heart-Attack Risk Hiding in Your Immune Cells
A blood mutation called CHIP turns your own immune cells against your arteries, and it is the cleanest case study I know for how the biology of aging drives chronic disease.
The Gut May Be the Point: Metformin, Citrulline, and the Exercise Question
A new Nature Metabolism paper places metformin's main effect in the gut, not muscle. That eases one exercise-blunting fear and raises a sharper one: citrulline and nitric oxide.
I Trained Hard for 25 Years. I Was Measuring the Wrong Fitness.
I trained hard for 25 years and never once measured my cardiorespiratory fitness. A hard program isn't a complete one, and the system you train best hides the ones you never test.
What Twenty Years of “Borderline” Blood Pressure Actually Costs You
A single 132/85 at 35 isn’t a snapshot. It’s a 20-year dose your arteries are already logging, and “borderline” is the word that hides the bill.