Does your longevity routine actually amount to anything?
The evidence behind the health claims, from a scientist who built health and wellness companies.
I’m Nick Hanson. Fifteen years building supplement and wellness companies, then cancer-epigenetics research, a PhD in computational biology in progress, and the emergency department at Mayo Clinic.
No sponsors. · No supplement line. · No cheerleading.
Coming December 2026
Evidence-based longevity intelligence.
Every supplement, drug and habit in your routine, checked against the biology of aging, the human evidence, and who paid for the studies.
- Which parts of aging you cover, and which whole systems go untouched.
- Where you are paying for overlap: several items doing the same job.
- How many of the studies behind each item were run by the maker.
Members will also get new-evidence alerts on their own stack, a safety radar, and a way to submit interventions and studies for review.
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The Five Filters
A repeatable framework for evaluating health and longevity claims before they become advice.
Aging Biology
What biology is this supposed to change?
Which hallmarks of aging, upstream systems, or molecular pathways does the claim touch?
Clinical Reality
Does it matter in actual humans?
Is the effect meaningful for real people, or does it mostly live in a biomarker, dish, mouse, or marketing deck?
Evidence Quality
How strong is the evidence?
Is the claim supported by hard outcomes, randomized trials, human biomarkers, observational data, animal models, cell studies, or mechanism alone?
Systems Biology
What happens when you push the pathway?
Biology is not a single switch. What else does the pathway do in context, and what tradeoffs might come with moving it?
Incentives
Who benefits if you believe it?
Who profits if the claim becomes popular, and who pays the price if it is wrong?
The biology behind the first filter:the hallmarks of aging. The filters as written rules:how we grade the evidence.
Start with these
The framework, a daily habit, and a supplement claim: three ways the same method reads the evidence.
I Went Into Research to Study Aging. Then I Needed a Stent at 44.
What aging biology can tell us about the supplements, tests and habits we pay for: the 12 hallmarks of aging, plus a candidate 13th, in plain English.
Is Your Mouthwash Increasing Your Blood Pressure?
Some mouthwashes shut down the tongue bacteria your body uses to make nitric oxide. What chlorhexidine does to blood pressure, and which rinse didn't.
The Longevity Compound Promoted on Half a Mechanism
5-Amino-1MQ, the NNMT inhibitor sold for fat loss and longevity: injected-mouse results, efficacy studies from the lab behind the patent, zero human trials.
Latest
Two Big Glasses of Wine a Night Is Officially “Heavy Drinking”
One or two glasses of red wine with dinner. Not a night out. The next morning my overnight heart rate was up as much as 20 percent, and my heart rate variability was cut by as much as half.
What Keeps Plaque in Your Heart Arteries From Rupturing?
Is soft plaque dangerous? Whether a plaque ruptures depends on its fibrous cap, which no CT report measures. What thins it, and the trials where caps thickened.
Your Angiogram Was Clean. Nobody Tested Whether Your Artery Clamps.
Coronary artery spasm is diagnosed with an acetylcholine test in the cath lab, not an angiogram. What it measures, why it is rarely run, how drugs blunt it.
Why this exists
I did most of what the optimization world recommends. I still had an 80% coronary blockage at 44.
Two cardiologists fixed the artery. Neither was much interested in why it had happened to a lifelong athlete with no family history and low inflammation markers. That question, why the biology went wrong upstream of the diagnosis, is the whole site.
The Four Worlds
Four worlds that shape how I evaluate every health claim.
Bedside
Where statistics become clinical judgment.
A p-value is not a patient. Bedside medicine trains you to separate statistical significance from clinical significance, and to ask whether a finding actually changes risk, decisions, or outcomes.
Mayo Clinic ED RN, CEN. APRN-FNP candidate at Duke.
Bench
Where health claims meet biological mechanism.
Bench science, molecular biology, and bioinformatics train you to ask what a claim is actually acting on: which pathway, which hallmark of aging, which molecular signal, and whether the data supports the story being sold.
MS, Bioinformatics & Computational Biology. Published epigenetics and oncology research. PhD candidate — UMN/Mayo Clinic.
Boardroom
Where plausible mechanisms become marketing copy.
Fifteen years inside the supplement and wellness industry taught me how health claims get built: how mechanisms become promises, how weak evidence gets inflated, and how incentives shape what consumers are told.
Former supplement industry CEO. No supplement line. No supplement affiliates. No sponsors. Ever.
Patient
Where the optimization playbook missed the risk.
At 44, an 80% coronary blockage forced me to confront the gap between predominant biohacker influencer advice and real cardiovascular risk. I was doing many of the things the longevity world celebrates, but the narrative was incomplete.
One investigation a week. No sponsors.
Each one takes a health claim you have already heard and reads the human evidence, the biology of aging behind it, and who paid for the studies.