Topic

Cardiovascular Risk

How the systems most likely to decide your lifespan actually break down: LDL and ApoB, blood pressure, the endothelium, coronary calcium, the dose-response math nobody teaches you.

13 articles

Featured card: Is Your Mouthwash Increasing Your Blood Pressure? A bottle labeled ANTIBACTERIAL MOUTHWASH in front of a cutaway artery whose lining glows as nitric oxide drifts into the blood. Antibacterial mouthwash, nitric oxide and blood pressure.
InterventionsCardiovascular Risk

Is Your Mouthwash Increasing Your Blood Pressure?

Some mouthwashes shut down the tongue bacteria your body uses to make nitric oxide. What chlorhexidine does to blood pressure, and which rinse didn't.

Oct 4, 2026 · 13 min read
Calibrated Signal featured card: What Keeps Plaque in Your Heart Arteries From Rupturing? A cutaway of a coronary artery plaque whose thin fibrous cap is tearing open above an amber lipid core, with a clot forming at the tear.
Cardiovascular RiskAging Biology

What Keeps Plaque in Your Heart Arteries From Rupturing?

Is soft plaque dangerous? Whether a plaque ruptures depends on its fibrous cap, which no CT report measures. What thins it, and the trials where caps thickened.

Sep 24, 2026 · 21 min read
Nick Hanson lying in a hospital bed in a patient gown with a cold cloth on his forehead and IV lines in both arms, the day of his coronary artery spasm diagnosis workup.
Patient AdvocacyDiagnostic Toolkit

I Finally Have the Diagnosis That Explains Years of Chest Pressure. It Wasn't Anxiety. It Was Never "All in My Head."

A stent didn't stop the episodes. Every scan said fine. The answer came from the one test I almost turned down.

Aug 31, 2026 · 14 min read
Calibrated Signal hero card for I Crushed My ApoB to 38, Nobody Measured My Small Vessels: a wide open coronary artery in cross-section branching downstream into a dense network of tiny inflamed red micro-vessels, the coronary microvasculature.
Cardiovascular RiskAging Biology

I Crushed My ApoB to 38. Nobody Measured My Small Vessels.

Coronary microvascular dysfunction hides behind a clean angiogram. How it is diagnosed, why inflammation drives it, and why an ApoB of 38 was not enough.

Jul 27, 2026 · 14 min read
Calibrated Signal hero card for The Heart Attacks You Never Feel, on how a coronary blockage can be built by silent plaque ruptures.
Cardiovascular RiskPatient Advocacy

The Heart Attacks You Never Feel

What happens when coronary plaque ruptures and heals instead of killing you: a silent wound that narrows the artery. It likely built my 80% blockage at 44.

Jun 20, 2026 · 11 min read
Calibrated Signal article hero card for The Plaque a Calcium Score Can't See, contrasting a calcium-only heart scan with a coronary CT angiogram that reveals soft plaque.
Diagnostic ToolkitCardiovascular Risk

The Plaque a Calcium Score Can't See

A calcium score only sees calcified plaque. Mine would have read zero with a severe soft-plaque blockage in place. What a 0 rules out, and what it doesn't.

Jun 11, 2026 · 10 min read
Calibrated Signal article hero: I Trained Hard for 25 Years. I Was Measuring the Wrong Fitness. A lean, dark-haired man in his 40s stands facing a dim gym mirror, studying his own muscular reflection.
Cardiovascular RiskAging Biology

I Trained Hard for 25 Years. I Was Measuring the Wrong Fitness.

VO2 max carries one of the strongest survival signals in medicine, with no ceiling found. I lifted five hours a week for 25 years and never measured mine once.

May 27, 2026 · 17 min read
Calibrated Signal featured card: Blood Pressure Isn’t a Moment. It’s a Dose Your Arteries Absorb for Decades, over a blood-pressure cuff beside a monitor showing a continuous arterial waveform.
Cardiovascular RiskAging Biology

Blood Pressure Isn’t a Moment. It’s a Dose Your Arteries Absorb for Decades.

132/85 is now Stage 1 hypertension, and a single reading is one sample of a dose your arteries absorb every beat, for decades. Mine sat there for twenty years.

May 14, 2026 · 22 min read
Calibrated Signal featured card: What Twenty Years of “Borderline” LDL Actually Costs You — an hourglass whose falling sand is made of copper cholesterol particles.
Cardiovascular Risk

What Twenty Years of “Borderline” LDL Actually Costs You

An LDL of 145 at 35 isn’t a snapshot. It’s 2,175 mg-years of exposure your arteries have already logged, and “borderline” is the word that hides the bill.

May 2, 2026 · 18 min read
Calibrated Signal featured card: Metabolically Healthy Isn’t a Diagnosis, a coronary artery cross-section with soft yellow plaque on dark navy.
Evidence CritiqueCardiovascular Risk

I Was “Metabolically Healthy.” I Got a Stent at 44 Anyway.

Low hsCRP, flat CGM, no insulin resistance, LDL 150s on keto: every marker the low-carb world calls safe. Then a CT angiogram found an 80% blockage at 44.

Apr 24, 2026 · 14 min read
Calibrated Signal featured card: I Was Doing Almost Everything Right. It Wasn’t Enough. — a dark navy still life of a smartwatch, ring, recovery devices, and a glowing red-light therapy panel.
Cardiovascular RiskPatient Advocacy

I Was Doing Almost Everything Right. It Wasn’t Enough.

The perfect biohacker résumé: 30 years of training, a supplement stack, wearables, clean labs. None of it measured the artery wall where an 80% blockage grew.

Apr 12, 2026 · 10 min read
Calibrated Signal featured card: The Battle for the Coronary Artery Scan That Saved My Life, a translucent heart inside a coronary CT angiography scanner ring on dark navy.
Diagnostic ToolkitPatient Advocacy

The Battle for the Coronary Artery Scan That Saved My Life

ECG, echo, Holter, stress test: all normal. A coronary CT angiogram (CCTA) found an 80% blockage anyway. What it shows, and the exact words to ask for it.

Mar 30, 2026 · 14 min read
Calibrated Signal featured card: The Keto Study Used to Dismiss LDL, Then It Was Retracted — an artery cross-section with glowing plaque on dark navy.
Evidence CritiqueCardiovascular Risk

The Study the Keto Community Uses to Say LDL Doesn’t Matter. Then the Follow-Up Got Retracted.

The Keto-CTA follow-up was retracted in 2026 at the authors' and editors' request over methodology. What soft plaque did in one year, and why LDL still matters.

Mar 27, 2026 · 16 min read